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Background  To our knowledge, there are no studies to systematically compare the detailed clinical significance between curatively resected pancreatic head (ph) and body-tail (pbt) ductal adenocarcinoma based on the new 8th edition of AJCC staging system (8th AJCC stage) that was just applied in clinical practice in 2018.    Methods  Three hundred fifty-one patients with curatively resected pancreatic adenocarcinoma (PC) from three center hospitals were entered into this multicenter cohort study.    Results  Increasing tumor size ( P  < 0.001), T stage (T1 + T2 vs T3 + T4,  P  = 0.003), frequent postoperative liver metastasis (PLM) ( P  = 0.002) and 8th AJCC stage (IA to VI,  P  < 0.001; I + II vs III + IV,  P  = 0.002) were closely associated with the progression of pbt cancers compared with that in ph cancer patients. Moreover, tumor size≥3 cm ( P  = 0.012), 8th AJCC stage (III + IV) ( P  = 0.025) and PLM ( P  = 0.010) were identified as independent risk factors in pbt cancers in logistic analysis. Patients with pbt cancers had a significantly worse overall survival compared with ph cancer patients ( P  = 0.003). Moreover, pbt was an independent unfavorable factor in multivariate analysis ( P  = 0.011). In addition to lymph nodes metastasis, 8th AJCC stage, vascular invasion and PLM, increasing tumor size and advanced T stage were also closely associated with the poor prognosis in 131 cases of pbt cancer patients compared with Ph cancer patients.    Conclusion  Pbt, as an independent unfavorable factor for the prognosis of PC patients, are much more aggressive than that in ph cancers according to 8th AJCC staging system. 8th AJCC staging system are more comprehensive and sensitive to reflect the malignant biology of pbt cancers.

bmc cancer

The diversity between curatively resected pancreatic head and body-tail cancers based on the 8th edition of AJCC staging system: a multicenter cohort study