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Background  Single nucleotide polymorphisms (SNPs) in 3′-untranslated region (UTR) of genes related with cell-matrix adhesions and migration might affect miRNA binding and potentially affect the risk of cancer. The present study aimed to screen SNPs in 3′ UTR of cancer-related genes and investigate their contribution to the susceptibility of lung cancer.    Methods  Seven SNPs were selected and genotyped in a case-control study (322 lung cancer patients and 384 controls) among Chinese Han population. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression adjusted for age and gender in multiple genetic models.    Results  In stratified analyses by gender, three (rs1064607, rs3796283 and rs2378456) of  LPP  gene were associated with a significantly increased susceptibility for lung cancer among male population. Besides,  LPP  rs2378456 weakened lung cancer risk in female.  LPP  rs1064607 polymorphism was significantly correlated with increased risk of lung adenocarcinoma. Furthermore, AA genotype of  TNS3  rs9876 polymorphism was associated with lymphatic metastasis.    Conclusion  Our results provides evidence for the impact of  LPP  polymorphisms on the susceptibility to lung cancer in Chinese population.    Electronic supplementary material  The online version of this article (10.1186/s12885-018-5241-5) contains supplementary material, which is available to authorized users.

Single nucleotide polymorphism in the 3′ untranslated region of LPP is a risk factor for lung cancer: a case-control study