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Background  Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients.    Methods  Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with  P -values< 10 − 5  were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2–4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used.    Results  In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population ( p -value< 0.05). The four smallest  P -values relevant to the nerve function were 0.0006 for rs8014839 (close to the  FBXO33  gene), 0.004 for rs4618330 (close to the  INTU  gene), 0.006 for rs1903216 (close to the  BCL6  gene) and 0.03 for rs4687753 (close to the  IL17RB  gene).    Conclusions  Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system.    Electronic supplementary material  The online version of this article (10.1186/s12885-018-4728-4) contains supplementary material, which is available to authorized users.

Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients