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Background  This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL).    Methods  A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database inception to March 2016. A total of 21 studies were included.    Results  Patients with positive MRD prior to allogeneic stem cell transplantation (allo-SCT) had a significantly higher rate of relapse compared with those with negative MRD (HR = 3.26;  P  <  0.05). Pre-transplantation positive MRD was a significant negative predictor of relapse-free survival (RFS) (HR = 2.53;  P  <  0.05), event-free survival (EFS) (HR = 4.77;  P  < 0.05), and overall survival (OS) (HR = 1.98;  P  < 0.05). However, positive MRD prior to transplantation was not associated with a higher rate of nonrelapse mortality.    Conclusions  Positive MRD before allo-SCT was a predictor of poor prognosis after transplantation in ALL.    Trial registration  Not applicable.    Electronic supplementary material  The online version of this article (10.1186/s12885-018-4670-5) contains supplementary material, which is available to authorized users.

bmc cancer

Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis