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Background  Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of the  CYP2A6*2 rs1801272  and  CYP2A6*9 rs28399433  gene polymorphisms and tobacco smoking in the risk of lung cancer in an Egyptian population.    Methods  A case-control study was conducted on 150 lung cancer cases and 150 controls. All subjects were subjected to blood sampling for Extraction of genomic DNA and Genotyping of the  CYP2A6  gene SNPs ( CYP2A6*2 (1799 T > A) rs1801272  and  CYP2A6*9 (− 48 T > G)  rs28399433 by Real time PCR.    Results  AC and CC genotypes were detected in  CYP2A6*9 ; and AT genotype in  CYP2A6*2.  The frequency of  CYP2A6*2  and  CYP2A6*9  were 0.7% and 3.7% respectively in the studied Egyptian population. All cancer cases with slow metabolizer variants were NSCLC. Non-smokers represented 71.4% of the  CYP2A6  variants. There was no statistical significant association between risk of lung cancer, smoking habits, heaviness of smoking and the different polymorphisms of  CYP2A6  genotypes.    Conclusion  The frequency of slow metabolizers  CYP2A6*2  and  CYP2A6*9  are poor in the studied Egyptian population. Our findings did not suggest any association between  CYP2A6  genotypes and risk of lung cancer.

bmc cancer

Association of genetic polymorphisms CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 with tobacco-induced lung Cancer: case-control study in an Egyptian population