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Background  The association of genes  XRCC1, TP53  and  MDM2  with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers  Arg399Gln  of gene  XRCC1, Arg72Pro  of gene  TP53 , and  T309G  of gene  MDM2  with the risk of BC in Kyrgyz women.    Methods  This was a case-control study of 219 women of Kyrgyz origin with morphologically verified BC ( N  = 117) and 102 controls, age-matched with BC cases. The mean age of subjects in this study was 52.2 ± 10.8 years. We extracted DNA from the venous blood and genotyped polymorphic markers  Arg399Gln  of gene  XRCC1 ,  Arg72Pro  of gene  TP53  and  T309G  of gene  MDM2  using polymerase chain reaction and the method of restriction fragment polymorphism.    Results  Allele  399Gln  (OR 1.57; 95% CI 1.05–2.35),  Arg399Gln  of gene  XRCC1  heterozygous genotype (OR 2.77; 95% CI 1.60–4.80), the combination of  Arg399Gln/Arg72Pro  of genes  XRCC1/TP53  heterozygous genotype (OR 3.98; 95% CI 1.57–10.09),  Arg399Gln/T309G  of genes  XRCC1/MDM2  (OR 3.0; 95% CI 1.18–7.56), as well as  Arg399Gln/Arg72Pro/T309G  of genes  XRCC1/TP53/MDM2  (OR 6.40; 95% CI 1.18–34.63) were associated with BC in Kyrgyz women.    Conclusions  This is the first study to identify the inter-loci interaction and to find molecular markers of individual risk of BC in Kyrgyz women.

The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females