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Background  To investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer (LACC).    Methods  A retrospective cohort study was conducted to examine LACC patients undergoing NACT and radical hysterectomy between 2002 and 2011. Patients were divided into three groups: patients without diabetes mellitus (DM), diabetic patients with good glycemic control, and diabetic patients with poor glycemic control. Hemoglobin A 1c  (HbA 1c ) levels were used to indicate glycemic control status. Recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) were analyzed using log-rank tests and Cox proportional hazards models.    Results  In total, 388 patients were included and had a median follow-up time of 39 months (range: 4–67 months). Diabetes mellitus (DM) was diagnosed in 89 (22.9%) patients, only 35 (39.3%) of whom had good glycemic control prior to NACT (HbA 1c  < 7.0%). In survival analysis, compared with patients with good glycemic control and patients without DM, patients with poor glycemic control (HbA 1c  ≥ 7.0%) exhibited decreased recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). In multivariate analysis, HbA 1c  ≥ 7.0% was identified as an independent predictor for decreased RFS (hazard ratio [HR] = 3.33,  P  < 0.0001), CSS (HR = 3.60,  P  < 0.0001) and OS (HR = 4.35,  P  < 0.0001). In the subgroup of diabetic patients, HbA 1c  ≥ 7.0% prior to NACT had an independent negative effect on RFS (HR = 2.18,  P  = 0.044) and OS (HR = 2.29,  P  = 0.012). When examined as a continuous variable, the HbA 1c  level was independently associated with decreased RFS (HR = 1.39,  P  = 0.002), CSS (HR = 1.28,  P  = 0.021) and OS (HR = 1.27,  P  = 0.004). Both good (odds ratio [OR] = 0.06,  P  < 0.0001) and poor glycemic control (OR = 0.04,  P  < 0.0001) were independently associated with a decreased likelihood of complete response following NACT.    Conclusions  Poor glycemic control is an independent predictor of survival and tumor response to chemotherapy for patients receiving NACT for LACC.    Electronic supplementary material  The online version of this article (doi:10.1186/s12885-017-3510-3) contains supplementary material, which is available to authorized users.

bmc cancer

Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease