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Background  Mannose-binding lectin (MBL) acts in the innate immune response to  Helicobacter pylori . Interleukin 8 (IL-8) is a potent cytokine produced by gastric epithelial cells in response to  H. pylori . We aimed to investigate whether polymorphisms in  MBL2  and  IL-8  influence susceptibility to  H. pylori  infection, and the associations of these polymorphisms with the risk of gastroduodenal diseases in a Korean population.    Methods  We consecutively enrolled 176  H. pylori -negative control subjects, 221 subjects with  H. pylori -positive non-atrophic gastritis, 52 mild atrophic gastritis (AG), 61 severe AG, 175 duodenal ulcer, and 283 gastric cancer (GC). Allele-specific PCR-RFLP was conducted for polymorphisms in  MBL2  exon 1 (codon 52, 54, and 57) and  IL-8  -251 T > A. IL-8 levels in gastric mucosal tissues and serum MBL levels were measured by enzyme-linked immunosorbent assay.    Results    MBL2  exon 1 polymorphic variants were found only in codon 54, and the allele frequencies did not differ significantly between the control and disease groups. Although serum MBL levels in codon 54  A/A  mutants were markedly low, it did not influence susceptibility to  H. pylori  infection or the risk of gastroduodenal diseases. IL-8 levels were significantly different between  T/T  wild type,  T/A  heterozygote, and  A/A  mutant genotypes.  IL-8  -251  A  allele carriers ( A/A  +  T/A ) showed increased IL-8 levels, and were significantly associated with the risk of severe AG and GC.    Conclusions  We suggest that a combination of  H. pylori  infection and the  IL-8  -251 T > A polymorphism might increase the risk of severe AG and GC in a Korean population.

bmc cancer

Combination of Helicobacter pylori infection and the interleukin 8 –251 T &gt; A polymorphism, but not the mannose-binding lectin 2 codon 54 G &gt; A polymorphism, might be a risk factor of gastric cancer