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Background  The Wnt signaling pathway is abnormally activated in many human cancers. Secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and play an important role in carcinogenesis.  SFRP  promoter hypermethylation has often been identified in human cancers; however, the precise role of  SFRPs  in cutaneous squamous cell carcinoma (SCC) is unclear.    Methods  The methylation status of the  SFRP  family was analyzed in an age-and sex-matched case-control study, including 40 cutaneous SCC cases and 40 normal controls, using the MassARRAY EpiTYPER system.    Results  The methylation rate of  SFRP1 ,  SFRP2 ,  SFRP4 , and  SFRP5  promoters was significantly higher in cutaneous SCC tissues than in adjacent tissue and normal skin samples.    Discussion  Our manuscript mainly discussed the average methylation rate of SFRPs (SFRP1, SFRP2, SFRP4, and SFRP5) promoters are significantly high in tumor tissue samples and the average CpG island methylation rate among different pathological levels of cutaneous SCC between these genes are different.    Conclusions  Our findings suggest that promoter hypermethylation of  SFRPs  is associated with the development of carcinoma, and could be a useful tumor marker for cutaneous SCC and other types of cancers.

Secreted frizzled-related protein promotors are hypermethylated in cutaneous squamous carcinoma compared with normal epidermis