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Background Gestational diabetes mellitus (GDM) is associated with adverse health consequences for women and their offspring. It is associated with maternal body mass index (BMI) and may be associated with gestational weight gain (GWG). But due to the heterogeneity of diagnosis and treatment and the potential effect of GDM treatment on GWG, the association between the two has not been thoroughly clarified. Compared to body weight, BMI has the advantage that it considers height during the whole course of pregnancy. Understanding BMI changes during pregnancy may provide new evidence for the prevention of GDM. Methods This study investigated the BMI change of pregnant women based on a retrospective study covering all communities in Tianjin, China. According to the results of GDM screening at 24–28 weeks of gestation, pregnancies were divided into the GDM group and the non-GDM group. We compared gestational BMI change and GWG in the two groups from early pregnancy to GDM screening. GWG was evaluated according to the IOM guidelines. Logistic regression was applied to determine the significance of variables with GDM. Results A total of 41,845 pregnant women were included in the final analysis (GDM group,  n  = 4257 vs. non-GDM group,  n  = 37,588). BMI gain has no significant differences between the GDM and non-GDM groups at any early pregnancy BMI categories (each of 2 kg/m 2 ), as well as weight gain ( P  &gt; 0.05). Early pregnancy BMI was a risk factor for GDM ( OR  1.131,  95% CI  1.122–1.139). And BMI gain was associated with a decreased risk of GDM in unadjusted univariate analysis ( OR  0.895,  95% CI  0.869–0.922). After adjusting on early pregnancy BMI and other confounding factors, the effect of BMI gain was no longer significant ( AOR  1.029,  95% CI  0.999–1.061), as well as weight gain ( AOR  1.006,  95% CI  0.995–1.018) and GWG categories (insufficient:  AOR  1.016,  95% CI  0.911–1.133; excessive:  AOR  1.044,  95% CI  0.957–1.138). Conclusions BMI in early pregnancy was a risk factor for GDM, while BMI gain before GDM screening was not associated with the risk of GDM. Therefore, the optimal BMI in early pregnancy is the key to preventing GDM.

bmc pregnancy and childbirth

Relationship between gestational body mass index change and the risk of gestational diabetes mellitus: a community-based retrospective study of 41,845 pregnant women