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Background  The investigation of CO 2  reactivity (CO 2 -CVR) is used in the setting of, e.g., traumatic brain injury (TBI). Transcranial color-coded duplex sonography (TCCD) is a promising bedside tool for monitoring cerebral hemodynamics. This study used TCCD to investigate CO 2 -CVR in volunteers, in sedated and mechanically ventilated patients without TBI and in sedated and mechanically ventilated patients in the acute phase after TBI.    Methods  This interventional investigation was performed between March 2013 and February 2016 at the surgical ICU of the University Hospital of Zurich. Ten volunteers (group 1), ten sedated and mechanically ventilated patients (group 2), and ten patients in the acute phase (12–36 h) after severe TBI (group 3) were included. CO 2 -CVR to moderate hyperventilation (∆ CO 2  -5.5 mmHg) was assessed by TCCD.    Results  CO 2 -CVR was 2.14 (1.20–2.70) %/mmHg in group 1, 2.03 (0.15–3.98) %/mmHg in group 2, and 3.32 (1.18–4.48)%/mmHg in group 3, without significant differences among groups.    Conclusion  Our data did not yield evidence for altered CO 2 -CVR in the early phase after TBI examined by TCCD.    Trial registration  Part of this trial was performed as preparation for the interventional trial in TBI patients (clinicaltrials.gov  NCT03822026 , 30.01.2019, retrospectively registered).

Transcranial color-coded duplex sonography assessment of cerebrovascular reactivity to carbon dioxide: an interventional study