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Background  The cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes and associated systemic blood pressure changes has not been studied, even though blood pressure is a major driver of cerebral blood flow.    Methods  Transcranial DCS data from four studies measuring bilateral frontal microvascular cerebral blood flow in healthy controls ( n  = 15), patients with asymptomatic severe internal carotid artery stenosis (ICA,  n  = 27), and patients with acute ischemic stroke (AIS,  n  = 72) were aggregated. DCS-measured CBF was measured in response to a short head-of-bed (HOB) position manipulation protocol (supine/elevated/supine, 5 min at each position). In a sub-group (AIS,  n  = 26; ICA,  n  = 14; control,  n  = 15), mean arterial pressure (MAP) was measured dynamically during the protocol.    Results  After elevated positioning, DCS CBF returned to baseline supine values in controls ( p  = 0.890) but not in patients with AIS (9.6% [6.0,13.3], mean 95% CI,  p  < 0.001) or ICA stenosis (8.6% [3.1,14.0],  p  = 0.003)). MAP in AIS patients did not return to baseline values (2.6 mmHg [0.5, 4.7],  p  = 0.018), but in ICA stenosis patients and controls did. Instead ipsilesional but not contralesional CBF was correlated with MAP (AIS 6.0%/mmHg [− 2.4,14.3],  p  = 0.038; ICA stenosis 11.0%/mmHg [2.4,19.5],  p  < 0.001).    Conclusions  The observed associations between ipsilateral CBF and MAP suggest that short HOB position changes may elicit deficits in cerebral autoregulation in cerebrovascular disorders. Additional research is required to further characterize this phenomenon.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12883-021-02179-8.

bmc neurology

Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease