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Background  Genetic and environmental factors seem to have etiologic roles in multiple sclerosis (MS). Kuwait is regarded as medium to high risk country for MS. However, there is a paucity of published data on the risk factors for MS in Kuwait. Therefore, this matched case-control study examined the association between various factors including family history, stressful life events, exposure to tobacco smoke, vaccination history, comorbidities and MS risk in Kuwait.    Methods  Confirmed 110 MS cases and age (± 5 years), gender and nationality matched controls (1:1) were enrolled. A pre-tested structured questionnaire was used to collect the data through face-to-face interviews both from cases and controls. Conditional logistic regression was used to analyze the data.    Results  Among both cases and controls, majority were Kuwaiti (82.7%), and female (76.4%). Multivariable model showed that cases compared to controls were significantly more likely to have had a family history of MS (adjusted matched odds ratio (mOR adj ) = 5.1; 95% CI: 2.1–12.4;  p  < 0.001) or less likely to have been vaccinated against influenza A and B viruses before MS onset (mOR adj  = 0.4; 95% CI: 0.2–0.8;  p  = 0.010). None of the other variables considered were significantly related to MS status in this study.    Conclusions  Family history of MS had significantly direct, whereas, vaccination against influenza A and B viruses had inverse associations with MS status. Future studies may contemplate to verify the observed results.

A matched case-control study of risk factors associated with multiple sclerosis in Kuwait