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Background  CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features.    Methods  Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59 patients with oligodendroglial tumours were used. Differences between CIC mutation and CIC wild-type were tested using Chi-square test and binary logistic regression analysis.    Results  In univariate analysis, the clinical variables and MR features, which consisted 3 selected features (subventricular zone[SVZ] involvement, volume and seizure history) were associated with CIC mutation status (all  p  < 0.05). A multivariate logistic regression analysis identified that seizure history (no vs. yes odd ratio [OR]: 28.960, 95 confidence interval [CI]:2.625–319.49,  p  = 0.006) and SVZ involvement (SVZ- vs. SVZ+ OR: 77.092,  p  = 0.003; 95% CI: 4.578–1298.334) were associated with a higher incidence of CIC mutation status. The nomogram showed good discrimination, with a C-index of 0.906 (95% CI: 0.812–1.000) and was well calibrated. SVZ- group has increased (SVZ- vs. SVZ+, hazard ratio [HR]: 4.500,  p  = 0.04; 95% CI: 1.069–18.945) overall survival.    Conclusions  Absence of seizure history and SVZ involvement (−) was associated with a higher incidence of CIC mutation.    Electronic supplementary material  The online version of this article (10.1186/s12883-019-1362-y) contains supplementary material, which is available to authorized users.

Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status