English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Cutaneous leishmaniasis (CL) is well linked with immunogenetic factors. This study was undertaken to test the association of TNF-α − 308 and IFN-γ + 874 gene polymorphisms with the susceptibility of  Leishmania (L) species  among CL patients in central region of Saudi Arabia.    Methods  This is a case-control study involved 169 Saudi subjects with different  L. species  and 199 healthy controls from central region of Saudi Arabia. All subjects were characterized by TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms using PCR.    Results  Evaluation of genotyping and allelic frequency of TNF-α − 308 G/A in different  L. species  showed no significant association compared to controls ( p  > 0.05). Except, in cases of  L. tropica  that showed significantly higher TNF-α − 308 A versus G allele frequency ( p  = 0.0004). Evaluation of genotyping of IFN-γ + 874 (TT versus AA+AT recessive) and allelic frequency of IFN-γ + 874 (T versus A) showed significant higher in  L. major  and also in total CL cases as compared to healthy controls ( p  < 0.05). Furthermore, a strong association was observed between the susceptibility of  L. major ,  L. tropica or  total CL cases with synergistically combined high TNF-α 308/INF-γ 874 alleles.    Conclusions  This is the first report that shows the gene polymorphisms of TNF-α − 308 G/A and IFN-γ + 874 A/T in Saudi patients with different  L. species  infections .  Data showed that the TNF-α-308 G/A gene polymorphism is not associated with the susceptibility of CL in Saudi subjects. The only correlation was found in between A versus G allelic frequency in  L. tropica.  Importantly, IFN-γ + 874 A/T polymorphism was found to be associated with the susceptibility of  L. major  and also with total CL subjects. Moreover, data from synergistically combined high TNF-α 308/INF-γ 874 alleles strongly suggest their potential role in the susceptibility of leishmania infection.

TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis