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Background  Herein, we collected currently published data to comprehensively evaluate the impact of the  FCGR2A  (Fc fragment of IgG receptor IIa) rs1801274 and  MUC5B  (mucin 5B, oligomeric mucus/gel-forming) rs35705950 variations on susceptibility to pneumonia diseases.    Methods  We retrieved case-control studies from three online databases and applied the statistical approach of meta-analysis for a series of pooling analyses.    Results  A total of fourteen case-control studies were included for  FCGR2A  rs1801274; while thirty-one case-control studies were included for  MUC5B  rs35705950. No significant difference between pneumonia cases and controls for  FCGR2A  rs1801274 was found. However,  MUC5B  rs35705950 was significantly associated with pneumonia susceptibility in the whole population under the genetic models of allelic T vs. G [OR (odds ratio) =3.78], carrier T vs. G (OR = 3.31), TT vs. GG (OR = 13.66), GT vs. GG (OR = 4.78), GT + TT vs. GG (OR = 5.05), and TT vs. GG + GT (OR = 6.47) (all  P  < 0.001, Bonferroni-adjusted  P  < 0.006; false discovery rate-adjusted  P  < 0.0010). Furthermore, we observed a similar positive result for subgroup analyses of “Caucasian”, “Asian”, “population-based control”, and “idiopathic pulmonary fibrosis”.    Conclusions   MUC5B  rs35705950, but not  FCGR2A  rs1801274, increases susceptibility to clinical pneumonia, especially to idiopathic pulmonary fibrosis, in both the Caucasian and Asian populations.

Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility