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Background  Several obesity susceptibility loci in genes, including  GNPDA2 ,  SH2B1 ,  TMEM18 ,  MTCH2 ,  CDKAL1 ,  FAIM2 , and  MC4R , have been identified by genome-wide association studies. The purpose of this study was to investigate whether these loci are associated with the concurrence of obesity and type 2 diabetes in Chinese Han patients.    Methods  Using the SNaPshot technique, we genotyped seven single nucleotide polymorphisms (SNPs) in 439 Chinese patients living in Northeast China who presented at The Second Hospital of Jilin University. We analyzed the associations between these seven alleles and clinical characteristics.    Results  Risk alleles near  TMEM18  (rs6548238) were associated with increased waist circumference, waist/hip ratio, body mass index (BMI), fasting plasma glucose, hemoglobin A1c, diastolic blood pressure, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol; risk alleles of  CDKAL1  (rs7754840) were associated with increased waist circumference and waist/hip ratio; and  FAIM2  (rs7138803) risk alleles were linked to increased BMI, diastolic blood pressure, and triglycerides (all  P  < 0.05). After adjusting for sex and age, loci near  TMEM18  (rs6548238) and  FAIM2  (rs7138803), but not  SH2B1  (rs7498665), near  GNPDA2  (rs10938397),  MTCH2  (rs10838738) and near  MC4R  (rs12970134), were associated with increased risk for type 2 diabetes in obese individuals.    Conclusion  We found that loci near  TMEM18  (rs6548238),  CDKAL1  (rs7754840), and  FAIM2  (rs7138803) may be associated with obesity-related indicators, and loci near  TMEM18  (rs6548238) and  FAIM2  (rs7138803) may increase susceptibility of concurrent type 2 diabetes associated with obesity.

Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients