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Background  Association of  GSTM1 - and  GSTT1 -null genotypes,  GSTP1  A/G gene polymorphism with renal cell carcinoma (RCC) susceptibility was detected, and the relationship between the  GSTM1 / GSTT1 -null genotype and clinical TNM stages of RCC was assessed, using meta-analysis method.    Methods  Association investigations according to eligibility criteria were searched and identified from the databases of Cochrane Library, PubMed, and Embase from establishment time of databases to July 1, 2017, and eligible reports were analyzed by meta-analysis. 95% confidence intervals (CI) were also detected, and odds ratios (OR) was used to express the results for dichotomous data.    Results  This meta-analysis indicated that there was no an association between  GSTM1 -null genotype,  GSTT1 -null genotype,  GSTP1  A/G gene polymorphism and RCC risk in the overall population of Caucasians or Asians. The dual  GSTM1–GSTT1 -null genotype was also not associated with RCC in the overall population of Caucasians. Interestingly, there was an association between the dual  GSTM1-GSTT1 -null genotype and the susceptibility of RCC in Asians. Relationship of the  GSTM1 -null genotype with clinical TNM stage of RCC was not observed in the overall population of Asians or Caucasians. In this meta-analysis, no association between the  GSTT1 -null genotype and clinical TNM stage of RCC was observed in Caucasians or Asians. Interestingly,  GSTT1 -null genotype was detected to be associated with the clinical TNM stages in patients with RCC in the overall population.    Conclusion  The dual  GSTM1-GSTT1 -null genotype is detected to be associated with the onset of RCC in Asians, and there is an association between the  GSTT1 -null genotype and the clinical TNM stages in patients with RCC in the overall population.    Electronic supplementary material  The online version of this article (10.1186/s12881-018-0620-y) contains supplementary material, which is available to authorized users.

A systematic review and meta-analyses of the relationship between glutathione S-transferase gene polymorphisms and renal cell carcinoma susceptibility