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Background  Genetic variations in key DNA repair genes may influence DNA repair capacity, DNA damage and breast carcinogenesis. The current study aimed to estimate the association of  APEX1  and  OGG1  polymorphisms with the risk of breast cancer development.    Methods  A total of 518 patients with histopathologically confirmed breast cancer and 921 region- and age-matched cancer-free controls were genotyped for the  APEX1  polymorphisms rs3136817 and rs1130409 and the  OGG1  polymorphisms rs1052133 and rs2072668 using a QuantStudio™ 12 K Flex Real-Time PCR System.    Results  The rs3136817 heterozygous TC genotype along with the rs3136817 dominant model (TC + CC) was strongly associated with breast cancer susceptibility (odds ratio [OR] = 0.670, 95% confidence interval [95% CI]: 0.513 - 0.873,  P  = 0.003; OR = 0.682, 95% CI: 0.526 - 0.883,  P  = 0.004, respectively). No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk. Furthermore, an allele combination analysis revealed that  APEX1  haplotypes containing C-T (alleles rs3136817 and rs1130409) conferred a significantly lower risk (corrected  P  < 0.001).    Conclusion  This research is the latest report showing that an  APEX1  rs3136817 heterozygous genotype may have a positive influence on DNA repair capacity in patients with breast cancer and thus may have a potential protective effect for Chinese Han women.    Electronic supplementary material  The online version of this article (10.1186/s12881-018-0578-9) contains supplementary material, which is available to authorized users.

Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China