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Background  Platelet Endothelial Aggregation Receptor 1 (PEAR1), a membrane protein highly expressed in platelets and endothelial cells, plays a role in platelet contact-induced activation, sustained platelet aggregation and endothelial function. Previous reports implicate  PEAR1 rs12041331  as a variant influencing risk in patients with coronary heart disease. We investigated whether genetic variation in  PEAR1  predicts cardiovascular outcome in a white population.    Methods  In 1938 participants enrolled in the Flemish Study on Environment, Genes and Health Outcomes (51.3% women; mean age 43.6 years), we genotyped 9 tagging SNPs in  PEAR1 , measured baseline cardiovascular risk factors, and recorded Cardiovascular disease incidence. For SNPs, we contrasted cardiovascular disease incidence of minor-allele heterozygotes and homozygotes (variant) vs. major-allele homozygotes (reference) and for haplotypes carriers vs. non-carriers. In adjusted analyses, we accounted for family clusters and baseline covariables, including sex, age, body mass index, mean arterial pressure, the total-to-HDL cholesterol ratio, smoking and drinking, antihypertensive drug treatment, and history of cardiovascular disease and diabetes mellitus.    Results  Over a median follow-up of 15.3 years, 238 died and 181 experienced a major cardiovascular endpoint. The multivariable-adjusted hazard ratios of eight  PEAR1  SNPs, including  rs12566888 , ranged from 0.87 to 1.07 ( P  ≥0.35) and from 0.78 to 1.30 ( P  ≥0.15), respectively. The hazard ratios of three haplotypes with frequency ≥10% ranged from 0.93 to 1.11 ( P  ≥0.49) for mortality and from 0.84 to 1.03 ( P  ≥0.29) for a cardiovascular complications. These results were not influenced by intake of antiplatelet drugs, nonsteroidal anti-inflammatory drugs, or both ( P -values for interaction ≥ 0.056).    Conclusions  In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that  PEAR1  might be a susceptibility gene for cardiovascular complications.    Electronic supplementary material  The online version of this article (doi:10.1186/s12881-017-0411-x) contains supplementary material, which is available to authorized users.

PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population