English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.    Methods  In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score - GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age 2 , sex, MI (yes/no), and population substructure.    Results  Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allele of the GRS was associated with 0.04 (SE = 0.01) kg/m 2  higher BMI ( P  = 4.5 × 10 −14 ). We observed nominal evidence of interactions of  CLIP1  rs11583200 ( P  interaction  = 0.014),  CADM2  rs13078960 ( P  interaction  = 0.037) and  GALNT10  rs7715256 ( P  interaction  = 0.048) with physical activity, and  PTBP2  rs11165643 ( P  interaction  = 0.045),  HIP1  rs1167827 ( P  interaction  = 0.015),  C6orf106  rs205262 ( P  interaction  = 0.032) and  GRID1  rs7899106 ( P  interaction  = 0.043) with smoking on BMI.    Conclusions  Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity.    Electronic supplementary material  The online version of this article (doi:10.1186/s12881-015-0259-x) contains supplementary material, which is available to authorized users.

Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study