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Background  The autoimmune thyroid diseases (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are caused by interactions between susceptibility genes and environmental triggers. Single nucleotide polymorphisms (SNPs) of Solute carrier family 22, member 4 ( SLC22A4 ) have been shown to be associated with several autoimmune diseases, including Crohn’s disease (CD) and rheumatoid arthritis (RA). The aim of this study is to investigate whether SNP rs3792876 in the  SLC22A4  gene is associated with GD, HT and AITD in a Chinese Han population.    Methods  In this study, we collected specimens from 553 Chinese Han individuals of 92 AITD pedigrees in 10 cities in Liaoning province, China (80 GD pedigrees, 478 members; 12 HT pedigrees, 75 members). SNP rs3792876 was genotyped using the TaqMan allelic discrimination assay. Hardy-Weinberg Equilibrium tests were performed among founders of the pedigrees using Haploview software. Family-based association tests performed using FBAT software.    Results  No deviation from Hardy-Weinberg equilibrium was observed ( p  > 0.05). There were not significant association between the  SLC22A4  gene polymorphism (rs3792876) and GD, HT and AITD was found.    Conclusions  These results suggest a lack of association between the  SLC22A4  gene polymorphism rs3792876 and susceptibility to GD, HT and AITD in a Chinese Han population.

Association of single nucleotide polymorphism rs3792876 in SLC22A4 gene with autoimmune thyroid disease in a Chinese Han population