English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Leptin ( LEP ) and adiponectin ( ADIPOQ ) genes encode adipokines that are mainly secreted by adipose tissues, involved in energy balance and suspected to play a role in the pathways linking adiposity to impaired glucose and insulin homeostasis. We have thus hypothesized that  LEP  and  ADIPOQ  DNA methylation changes might be involved in obesity development and its related complications. The objective of this study wa s  to assess whether  LEP  and  ADIPOQ  DNA methylation levels measured in subcutaneous (SAT) and visceral adipose tissues (VAT) are associated with anthropometric measures and metabolic profile in severely obese men and women. These analyses were repeated with DNA methylation profiles from blood cells obtained from the same individuals to determine whether they showed similarities.    Methods  Paired SAT, VAT and blood samples were obtained from 73 severely obese patients undergoing a bioliopancreatic diversion with duodenal switch.  LEP  and  ADIPOQ  DNA methylation and mRNA levels were quantified using bisulfite-pyrosequencing and qRT-PCR respectively. Pearson’s correlation coefficients were computed to determine the associations between  LEP  and  ADIPOQ  DNA methylation levels, anthropometric measures and metabolic profile.    Results  DNA methylation levels at the  ADIPOQ  gene locus in SAT was positively associated with BMI and waist girth whereas  LEP  DNA methylation levels in blood cells were negatively associated with body mass index (BMI). Fasting LDL-C levels were found to be positively correlated with DNA methylation levels at  LEP -CpG11 and -CpG17 in blood and SAT and with  ADIPOQ  DNA methylation levels in SAT (CpGE1 and CpGE3) and VAT (CpGE1).    Conclusions  These results confirm that  LEP  and  ADIPOQ  epigenetic profiles are associated with obesity. We also report associations between LDL-C levels and both  LEP  and  ADIPOQ  DNA methylation levels suggesting that LDL-C might regulate their epigenetic profiles in adipose tissues. Furthermore, similar correlations were observed between LDL-C and  LEP  blood DNA methylation levels suggesting a common regulatory pathway of DNA methylation in both adipose tissues and blood.    Electronic supplementary material  The online version of this article (doi:10.1186/s12881-015-0174-1) contains supplementary material, which is available to authorized users.

bmc medical genetics

Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women