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Background Retinal vessel segmentation benefits significantly from deep learning. Its performance relies on sufficient training images with accurate ground-truth segmentation, which are usually manually annotated in the form of binary pixel-wise label maps. Manually annotated ground-truth label maps, more or less, contain errors for part of the pixels. Due to the thin structure of retina vessels, such errors are more frequent and serious in manual annotations, which negatively affect deep learning performance. Methods In this paper, we develop a new method to automatically and iteratively identify and correct such noisy segmentation labels in the process of network training. We consider historical predicted label maps of network-in-training from different epochs and jointly use them to self-supervise the predicted labels during training and dynamically correct the supervised labels with noises. Results We conducted experiments on the three datasets of DRIVE, STARE and CHASE-DB1 with synthetic noises, pseudo-labeled noises, and manually labeled noises. For synthetic noise, the proposed method corrects the original noisy label maps to a more accurate label map by 4.0–   $$9.8\%$$  9.8 % on    $$F_1$$  F 1 and 10.7–   $$16.8\%$$  16.8 % on PR on three testing datasets. For the other two types of noise, the method could also improve the label map quality. Conclusions Experiment results verified that the proposed method could achieve better retinal image segmentation performance than many existing methods by simultaneously correcting the noise in the initial label map.

Self-relabeling for noise-tolerant retina vessel segmentation through label reliability estimation