English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Phosphatidylserine (PS)-targeting positron emission tomography (PET) imaging with labeled small-molecule tracer is a crucial non-invasive molecule imaging method of apoptosis. In this study, semi-automatic radiosynthesis and biodistribution of  N -(2- 18 F-fluoropropionyl)-bis(zinc(II)-dipicolylamine) ( 18 F-FP-DPAZn2), as a potential small-molecule tracer for PET imaging of cell death in Alzheimer’s disease (AD) model, were performed.    Methods    18 F-FP-DPAZn2 was synthesized on the modified PET-MF-2V-IT-I synthesizer. Biodistribution was determined in normal mice and PET images of AD model were obtained on a micro PET-CT scanner.    Results  With the modified synthesizer, the total decay-corrected radiochemical yield of  18 F-FP-DPAZn2 was 35 ± 6% ( n  = 5) from  18 F −  within 105 ± 10 min. Biodistribution results showed that kidney has the highest uptake of  18 F-FP-DPAZn2. The uptake of radioactivity in brain kept at a relatively low level during the whole observed time. In vivo  18 F-FP-DPAZn2 PET images demonstrated more accumulation of radioactivity in the brain of AD model mice than that in the brain of normal mice.    Conclusions  The semi-automatic synthetic method provides a slightly higher radiochemical yield and shorter whole synthesis time of  18 F-FP-DPAZn2 than the manual operation method. This improved method can give enough radioactivity and high radiochemical purity of  18 F-FP-DPAZn2 for in vivo PET imaging. The results show that  18 F-FP-DPAZn2 seems to be a potential cell death tracer for AD imaging.

Semi-automatic synthesis and biodistribution of N-(2-18F-fluoropropionyl)-bis(zinc (II)-dipicolylamine) (18F-FP-DPAZn2) for AD model imaging