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Background  HPV and  C.trachomatis  are the most prevalent, viral and bacterial STI worldwide. Both commonly have an asymptomatic development and can evolve into a persistent infection which, added to coinfections, may be important cofactors for the oncogenic transformation.    Objective  Evaluate the prevalence of oral and genital HPV and  C.trachomatis  infection in women with normal and abnormal cervical cytology.    Study design  The cross-sectional study included 200 swabs, 100 oral and 100 cervical from 50 women with normal and 50 with abnormal cervical cytology. HPV and  C.trachomatis  infections were detected using PCR with specific primers.    Results  HPV DNA was detected in 27% ( n  = 27/100) of women with normal and abnormal cytology. Out of 100 genital samples we detected HPV DNA in 18% ( n  = 18/100) and 14% ( n  = 14/100) out of 100 oral samples. HPV genotypes detected were genotype 6 of low-risk and 16, 31, 52, 58 and 16–31 coinfection of high-risk.  C.trachomatis  DNA was detected in 49% ( n  = 49/100) of patients. Out of 100 genital samples we detected  C.trachomatis  in 35% ( n  = 35/100) and 31% ( n  = 31) out of 100 oral samples. There is statistically significant ( p  < 0.05) between cytology and HPV and  C.trachomatis  infection but there is no statistically significant between cytology and the other characteristics.    Conclusions  Since the histology of oral mucosa resembles that of the uterine cervix, we can anticipate the presence of HPV and other STI which are detected in different lesions of genital areas and the oral mucosa. Therefore, is important  C.trachomatis  detection and specific treatment in asymptomatic women because this infection may increase the risk of HPV persistence and coinfection induces a pro-inflammatory environment that may promote the carcinogenesis.

Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology