English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Coagulase-negative staphylococci belonging to  S. haemolyticus ,  S. hominis  subsp.  hominis ,  S. simulans,  and  S. warneri  are often described as etiological factors of infections. Staphylococci are a phylogenetically coherent group; nevertheless, there are differences among the species which may be important to clinicians.    Methods  We investigated selected virulence factors and antibiotic resistance that were phenotypically demonstrated, the presence and expression of genes encoding the virulence factors, and the type of the SCCmec cassette.    Results  The differences between the tested species were revealed. A great number of isolates produced a biofilm and many of them contained single  icaADBC  operon genes. Clear differences between species in the lipolytic activity spectrum could be related to their ability to cause various types of infections. Our studies also revealed the presence of genes encoding virulence factors homologous to  S. aureus  in the analysed species such as enterotoxin and  pvl  genes, which were also expressed in single isolates of  S. simulans  and  S. warneri .  S. haemolyticus  and  S. hominis  subsp.  hominis  isolates were resistant to all clinically important antibiotics including ß-lactams. The identified SCC mec  cassettes belonged to IV, V, VII, and IX type but most of the detected cassettes were non-typeable. Among the investigated species,  S. hominis  subsp.  hominis  isolates accumulated virulence genes typical for  S. aureus  in the most efficient way and were widely resistant to antibiotics.    Conclusions  Our results clearly indicated significant differences between the tested species, which might be a result of the horizontal gene transfer (HGT) and can lead to the formation and selection of multi-drug resistant strains as well as strains with new virulence features. Such strains can have a new clinical relevance.

Staphylococcal species less frequently isolated from human clinical specimens - are they a threat for hospital patients?