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Background  Chronic Sedentary lifestyles have been linked to increased odds of stress, elevated anxiety and diminished wellbeing, inducing cytokine production and predispose to hypertension and other cardiovascular diseases. In endemic areas,  Plasmodium falciparum  and hepatitis B virus (HBV) infections can trigger pro-inflammatory cytokine responses. However, the impact of these infections on cytokine response profiles in individuals engaged in chronic sedentary activities is unknown. This study was aimed at addressing these concerns using a predominantly sedentary population of traders in the Tamale metropolis of Ghana.    Method  Four hundred respondents were categorized, based on their number of working years (< or ≥ 5 years) and number of working hours per day (< or ≥ 10 h), into sedentary ( ≥5 years + ≥ 10 h)  and non-sedentary ( ≥ 5 years + < 10 h, < 5 years + ≥ 10 h and <  5 years + < 10 h)  groups. The participants were tested for  P. falciparum  and HBV infections using polymerase chain reaction. Blood pressure and cytokines responses were measured. Associations and comparison analysis between variables were determined, and test statistics with  p < 0.05  were considered statistically significant.    Results  Infection status included: un-infected (93.5%),  P. falciparum  mono-infected (1.0%), HBV mono-infected (3.0%) or  P. falciparum  /HBV co-infected (2.5%). Majority of the participants, 57.0% ( n  = 228) were involved in chronic sedentary life style. That notwithstanding, sedentary lifestyle was independent of the infection groups  (χ   2    = 7.08, p = 0.629).  Hypertension was diagnosed in 53.8% of respondents and was independent of infection status  (X    2    = 6.33, p = 0.097).  Pro-inflammatory  (TNF-α, IL-1β, IL-6, IL-8 and IL-12)  and anti-inflammatory  (IL-10, IL-7 and IL-13)  cytokine responses were similar among individuals with different sedentary working time and between hypertensive and non-hypertensive individuals  (p > 0.05 for all comparisons).  Among individuals with different infection status, pro-inflammatory (TNF -α; p = 0.290, IL-1β; p = 0.442, IL-6; p = 0.686, IFN-γ; p = 0.801, IL-8; p = 0.546, IL-12; p = 0.154)  and anti-inflammatory ( IL-10; p = 0.201, IL-7; p = 0.190, IL-13; p = 0.763)  cytokine responses were similar.    Conclusion  Our data suggest that asymptomatic infections of  P. falciparum  and HBV together with a high prevalence of hypertension did not have any significant impact on cytokine response profiles among predominantly sedentary traders in the Tamale metropolis of Ghana.

Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities