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Background  Globally, in 2012, about 1.2 million estimated cases were reported with ~ 135,000 deaths annually. In Ethiopia, specifically in our study area, limited information is found on the oropharyngeal carriage, antimicrobial resistance pattern, and associated risk factors for  N. meningitidis  among school children. So, the aim of this study was to assess oropharyngeal carriage rate of  N. meningitidis,  antibiotic susceptibility pattern and associated risk factors among primary school children in Gondar town, Northwest Ethiopia.    Methods  A cross sectional study was conducted from January to April, 2019 in Gondar town. Multi stage simple random sampling technique was used. A total of 524 oropharyngeal swabs were collected using sterile plastic cotton swabs. Modified Thayer Martin media was used for primary isolation. Antimicrobial susceptibility pattern was done based on Kirby-Bauer method on Muller-Hinton agar supplemented with 5% sheep blood. Multidrug resistance was defined as resistance of an isolate to two or more antimicrobial classes tested. Logistic regression model was used to see the association between dependent variables (Carriage rate of  Neisseria meningitidis , Serogroups of  Neisseria meningitidis and  Antimicrobial susceptibility patterns) and independent variables (Socio-demographic data and risk factors). Variables with a  P - value ≤0.2 during bivariable analysis was taken to multivariable analysis to check significant association of meningococcal carriage with risk factors. Finally, a  P -value &lt; 0.05 was considered as statistically significant. Data was summarized using numbers, percentages and tables.    Results  A total of 53(10.1%) (CI: 7.6–12.8)  N. meningitidis  isolates were identified. Serogroup A 13 (24.5%) was the most prevalent followed by Y/W135 11(20.7%) whereas serogroup B 4(7.6%) was the least identified serotype. Meningococcal isolates were resistant to ciprofloxacin (45.3%) and trimethoprim-sulfamethoxazole (73.6%). Overall, most of meningococcal isolates showed about 32(60.4%) multidrug resistance. Meningococcal carriage rate was significantly associated with family size, tonsillectomy, passive smoking, number of students per class, sharing utensils, history of visiting healthcare institutions, and indoor kitchen.    Conclusion  This study highlights the need for reinforcement of case-based, laboratory confirmed surveillance of  N. meningitidis  carriage in Ethiopian elementary school students to enable mapping of distribution of serotypes of the causative organisms across the country and determine the current potential necessity of vaccination.

bmc infectious diseases

Carriage rate of Neisseria meningitidis, antibiotic susceptibility pattern and associated risk factors among primary school children in Gondar town, Northwest Ethiopia