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Background  IL-6 was associated with the severity of  mycoplasma pneumoniae  pneumonia (MPP). But the relationship between IL-27 and MPP was unknown.    Methods  Ninety-eight patients with MPP < 14 years old were enrolled in this study and divided into groups by severity (mild cases and severe cases), infection types ( MP  single infection group and  MP  mixed infection group) and DNA loads (low  MP  DNA loads group and high  MP  DNA loads group), respectively. Fifteen children with foreign bodies in bronchus were also enrolled as control. IL-6 s and IL-27 s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA.    Results  There were significant differences in IL-6 s of BALFs from patients between mild cases and severe cases,  MP  single infection group and  MP  mixed infection group, and low  MP  DNA loads group and high  MP  DNA loads group, respectively ( P  < 0.05). Compared with IL-6 s of BALFs from control, IL-6 s in BALFs from the 6 patient groups were significantly higher ( P  < 0.05). IL-27 s in BALFs from  MP  mixed infection group were significantly lower than those from  MP  single infection group and control ( P  < 0.05) respectively.    Conclusion  IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to  MP  infection.

The clinical significance of IL-6 s and IL-27 s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia