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Background  Vaginal candidiasis is frequent in pregnant women and is associated with sepsis and adverse neonatal outcomes. This study determined the prevalence of  candida  species in symptomatic pregnant women and evaluated the antifungal susceptibility profile of the isolated  Candida  strains. It also aimed to explore whether  Candida  species predicts gestational complications and adverse neonatal outcomes.    Methods  A total of 258 pregnant women with vaginal discharge at 35 to 37 week of gestation participated in this study. Vaginal swabs from these patients were collected at various obstetrics and gynecology clinics in Lebanon for a period of 14 months.  Candida  isolates were identified at species level and antifungal susceptibility of  Candida albicans  to fluconazole (FCZ), amphotericin B (AMB), itraconazole (ICZ) and voriconazole (VCZ) was determined by the agar-based E-test method.    Results  Among 258 women tested, 100 (39%) were positive for  Candida  species.  C. albicans, C. glabrata  and  C. krusei  were isolated from 42, 41 and 17% of the women, respectively.  C. albicans  was significantly associated only with gestational diabetes while  C. krusei  or  C. glabrata  had significant positive associations with other gestational complications. The antifungal susceptibility tests of  C. albicans  isolates revealed 97.5, 90, 87.5 and 97.5% susceptibility to AMB, FCZ, ICZ and VCZ, respectively.    Conclusion  The current study revealed high incidence of both  C. albicans  and non- C. albicans Candida  strains causing vulvovaginitis among pregnant women in Beirut, Lebanon.  Candida  screening as antenatal follow up is advised to minimize the risk of adverse neonatal outcome or gestational complications.

Prevalence and antifungal susceptibility of Candida albicans causing vaginal discharge among pregnant women in Lebanon