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Background  Toxoplasmosis is a common and serious parasitic infection caused by the ubiquitous obligatory intracellular protozoan organism,  Toxoplasma gondii . Although infection with  T. gondii  is usually asymptomatic in healthy individuals, it can lead to severe pathological effects in congenital cases and immunocompromised patients. This study aimed to determine the seroprevalence of  T. gondii  and its predictors among pregnant women seeking prenatal and medical care at the general maternal and child health facility in Dhamar district of Dhamar governorate, Yemen.    Methods  A total of 420 pregnant women were randomly selected for this cross-sectional study. Participants were screened for anti- T. gondii  antibodies (i.e. immunoglobulin M; IgM and immunoglobulin G; IgG) using electrochemiluminescence immunoassay. Demographic, socioeconomic, obstetric and behavioural data were collected using a pretested questionnaire via face-to-face interview. Univariate and multivariate analyses were used to identify the independent predictors of  T. gondii  seroprevalence.    Results  The overall seroprevalence of anti- T. gondii  antibodies (IgG and/or IgM) among the participants was 21.2% (89/420; 95% CI = 17.3–25.1). Anti- T. gondii  IgG antibodies were detected in 20.0% (84/420) of the women of which 12.9% (54/420) were positive for only IgG and 7.1% (30/420) were positive for both IgG and IgM antibodies. Moreover, 5 women (1.2%) were reactive only for IgM antibodies. Significant associations between  T. gondii  seroprevalence and history of spontaneous abortion ( P  <  0.001), raw vegetables consumption ( P  = 0.036), and presence of cats in household ( P  = 0.049) were reported. Multivariate analysis confirmed that history of spontaneous abortion (AOR = 4.04; 95% CI = [2.46, 6.63]) and presence of cats in household (AOR = 1.77; 95% CI = [1.02, 3.07]) are significant predictors of  T. gondii  seroprevalence among the studied participants.    Conclusion  The study found a high seroprevalence (21.2%) of  T. gondii  infection during pregnancy in Dhamar district, which is significantly associated with adverse pregnancy outcomes. The provision of adequate maternal healthcare and health education pertaining to the prevention of  T. gondii  infection is therefore imperative to curtail the prevalence of infection among the studied population.

Prevalence and predictors of Toxoplasma gondii infection in pregnant women from Dhamar, Yemen