English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Klebsiella variicola  and  K. quasipneumoniae  are new species distinguishable from  K. pneumoniae  but they are often misidentified as  K. pneumoniae  in clinical settings. Several reports have demonstrated the possibility that the virulence factors and clinical features differ among these three phylogroups. In this study, we aimed to clarify whether there were differences in clinical and bacterial features between the three phylogroups isolated from patients with bloodstream infections (BSIs) in Japan.    Methods  Isolates from all patients with BSIs caused by  K. pneumoniae  admitted to two hospitals between 2014 and 2017 ( n  = 119) were included in the study. Bacterial species were identified via sequence analysis, and their virulence factors and serotypes were analyzed via multiplex PCR results. Clinical data were retrieved from medical records.    Results  Of the 119 isolates, 21 (17.7%) were identified as  K. variicola  and 11 (9.2%) as  K. quasipneumoniae ; K1 serotype was found in 16 (13.4%), and K2 serotype in 13 (10.9%). Significant differences in the prevalence of  rmpA ,  iutA ,  ybtS ,  entB  and  kfu  ( p  < 0.001), and  allS  genes ( p  < 0.05) were found between the three phylogroups. However, there were no significant differences in clinical features, including the 30-day mortality rate, between the three organisms, although  K. variicola  was more frequently detected in patients over 80 years old compared with other  Klebsiella  species ( p  < 0.005), and  K. quasipneumoniae  more frequently occurred in patients with malignancy ( p  < 0.05).    Conclusions  Our findings demonstrated the differences in bacterial pathogenicity and clinical features among these three phylogroups. Further epidemiological studies into BSI caused by  Klebsiella  species are warranted.

bmc infectious diseases

Clinical characteristics in blood stream infections caused by Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae: a comparative study, Japan, 2014–2017