English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  In this study, the association between high-risk human papillomavirus (hrHPV) infection and the vaginal microbiome in pregnant women was evaluated in Chinese cohorts.    Methods  The vaginal bacterial composition of four groups, 38 hrHPV-infected pregnant women (PHR,  n  = 38), pregnant women without HPV infection (PN,  n  = 48), nonpregnant women with hrHPV infection (NPHR,  n  = 19) and nonpregnant women without HPV infection (NPN,  n  = 30), was characterized by deep sequencing of barcoded 16S rRNA gene fragments (V3–4) using Illumina MiSeq.    Results  The results revealed that both pregnancy and HPV infection can increase vaginal bacterial microbial richness and diversity, with the bacterial composition being most influenced by pregnancy.  Lactobacillus  was the most dominant genus among all samples. NPN samples were dominated by CST (community state type) III, mainly composed of  Lactobacillus iners . Both pregnancy and hrHPV infection were accompanied by an increased proportion of CST I (dominated by  Lactobacillus crispatus ), as opposed to CST III.  Bifidobacterium ,  Bacillus ,  Megasphaera ,  Sneathia ,  Prevotella ,  Gardnerella ,  Fastidiosipila  and  Dialister  were found to be biomarkers for hrHPV-infected women, though different genera ( Bifidobacterium ,  Megasphaera ,  Bacillus ,  Acidovorax ,  Oceanobacillus  and  Lactococcus ) were associated with hrHPV-infected pregnant women.    Conclusions  This work uncovered a probable synergistic effect of hrHPV infection and pregnancy on the vaginal microbial composition. HPV infection in pregnant women was associated with a more complex and diverse microbial environment.    Electronic supplementary material  The online version of this article (10.1186/s12879-019-4279-6) contains supplementary material, which is available to authorized users.

Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women