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Background  Hantaviruses are important zoonotic pathogens, and they pose a profound risk to public health. So far, there has been no evidence showing that Tula virus (TULV), one species of hantavirus, is endemic in China. In this study, we captured rodents and found that the Tula virus had infected voles in Yili region, Xinjiang, China.    Methods  Rodents were captured by flooding their burrows in mountain pasture areas in Narati, Xinyuan County, Xinjiang, China. Hantavirus L gene fragments were amplified by nest RT-PCR using genus-specific primers. Positive samples were further identified by sequencing of RT-PCR products of S gene fragment for species identification. To identify the species of captured small mammals, the rodents’ cytochrome b ( Cyt b) was amplified by PCR and sequenced. Phylogenetic analysis was used to show the clustering and evolution relationship of the viral nucleic acids.    Results  Here, 31 out of 198 voles captured (16%) were infected with TULV. Host sequencing analysis showed these voles were  Microtus obscurus  ( M. obscurs ). Alignment and phylogenetic analysis of the exon region (1191 bp) of the hantavirus S gene confirmed that all of the detected amplicons were TULV, which was similar to one strain of TULV identified in Kazakhstan.    Conclusion  This is the first identification of Tula virus in China, and we found that  M. obscurus  acts as a natural reservoir for carrying the virus. Although the infection rate in the local human population remains unknown, the high prevalence of TULV in the small mammals in the region constitutes a risk that this putative pathogen may spread to the local population.    Electronic supplementary material  The online version of this article (10.1186/s12879-019-4133-x) contains supplementary material, which is available to authorized users.

Molecular evidence of Tula virus in Microtus obscurus in the region of Yili, Xinjiang, China