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Background  Carbapenem resistance in  Acinetobacter baumannii  in China was mainly mediated by OXA-23-like carbapenemases, while OXA-24/40-like carbapenemases were rarely identified. OXA-72 is one variant of OXA-24/40-like carbapenemases. This study aimed to demonstrate the epidemiology and characterizations of OXA-72-producing  A. baumannii  in a Chinese hospital.    Methods  A total of 107 clinical  A. calcoaceticus - A. baumannii  (Acb) complex isolates were collected in a Chinese hospital during between 2014 and 2016. These isolates were identified using Vitek 2 system and  gyrB  multiplex PCR. Vitek 2 system was used for antibiotic susceptibility testing. Genes encoding for major classes of carbapenemases were investigated by PCR. Rep-PCR was used for genotyping of all the  A. baumannii  isolates. The risk factors for carriage of OXA-72-producing or OXA-23-producing  A. baumannii  were analyzed through univariate and multivariate logistic regression.    Results  Of the 107  Acb  isolates collected, 101 isolates (94.4%) and 6 isolates (5.6%) were identified as  A. baumannii  and  A. pittii , respectively. 78  A. baumannii  isolates (77.2%) were carbapenem resistant and mainly cultured from intensive care unit (ICU).  bla  OXA-72  and  bla  OXA-23  genes were identified in 45(57.7%) and 33(42.3%) carbapenem-resistant  A. baumannii  (CRAB), respectively. Multivariate risk factor analyses showed that prior carbapenem usage and nasogastric intubation were significantly associated with carriage of OXA-72-producing  A. baumannii  or OXA-23-producing  A. baumannii . Rep-PCR analysis showed that 9 and 22 Rep-PCR types were assigned to 78 CRAB isolates and 23 carbapenem-susceptible  A. baumannii  (CSAB) isolates, respectively. A higher diverstiy of Rep-PCR patterns was observed among OXA-72-producing  A. baumannii  isolates than OXA-23-producing  A. baumannii  isolates, but all of them belonged to the same clone complex. MLST analysis suggested that the OXA-72 isolates from this study correspond to CC92/CC2 clone complex.    Conclusions  This study demonstrates high prevalence and potential clonal spread of closely related genotypes of OXA-72-producing  A. baumannii  within a Chinese hospital. Continuous surveillance is necessary to monitor the dissemination of these strains in other healthcare settings to guide infection control policies in order to curb the spread of this bacterium.

High prevalence and clonal dissemination of OXA-72-producing Acinetobacter baumannii in a Chinese hospital: a cross sectional study