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Background  Respiratory syncytial virus (RSV) is the most important cause of severe acute respiratory tract infection in young children. Alere i RSV is a novel molecular rapid test which identifies respiratory syncytial virus in less than 13 min.    Methods  We evaluated the clinical performance of the Alere i RSV assay in a pediatric point-of-care setting during winter season 2016 / 2017. Test results from 518 nasopharyngeal swab samples were compared to a real-time reverse transcription PCR reference standard.    Results  The overall sensitivity and specificity of the Alere i RSV test assay was 93% (CI 95  89% – 96%) and 96% (CI 95  93% – 98%), respectively. Alere i RSV performed well in children of all age groups. An optimal sensitivity of 98% (CI 95  94% - 100%) and specificity of 96% (CI 95  90% - 99%) was obtained in children < 6 months. In children ≥ 2 years, sensitivity and specificity remained at 87% (CI 95  73% – 96%) and 98% (CI 95  92% – 100%), respectively. False negative Alere i RSV test results mostly occurred in samples with low viral load (mean CT value 31.1; CI 95  29.6 – 32.6). The Alere i RSV assay is easy to use and can be operated after minimal initial training. Test results are available within 13 min, with most RSV positive samples being identified after approximately 5 min.    Conclusion  The Alere i RSV assay has the potential to facilitate the detection of RSV in pediatric point-of-care settings.    Electronic supplementary material  The online version of this article (10.1186/s12879-017-2855-1) contains supplementary material, which is available to authorized users.

Performance of the Alere i RSV assay for point-of-care detection of respiratory syncytial virus in children