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Background  Antifungal susceptibility testing is a subject of interest in the field of medical mycology. The aim of the present study were the distributions and antifungal susceptibility patterns of various  Candida  species isolated from colonized and infected immunocompromised patients admitted to ten university hospitals in Iran.    Methods  In totally, 846  Candida  species were isolated from more than 4000 clinical samples and identified by the API 20 C AUX system. Antifungal susceptibility testing was performed by broth microdilution method according to CLSI.    Results  The most frequent  Candida  species isolated from all patients was  Candida albicans  (510/846). The epidemiological cutoff value and percentage of wild-type species for amphotericin B and fluconazole in  Candida albicans ,  Candida tropicalis ,  Candida glabrata  and  Candida krusei  were 0.5 μg/ml (95%) and 4 μg/ml (96%); 1 μg/ml (95%) and 8 μg/ml (95%); 0.5 μg/ml (99%) and 19 μg/ml (98%); and 4 μg/ml (95%) and 64 μg/ml (95%), respectively. The MIC90 and epidemiological cutoff values to posaconazole in  Candida krusei  were 0.5 μg/ml. There were significant differences between infecting and colonizing isolates of  Candida tropicalis  in MIC 90 values of amphotericin B, and isolates of  Candida glabrata  in values of amphotericin B, caspofungin, and voriconazole ( P  < 0.05).    Conclusions  Our findings suggest that the susceptibility patterns of  Candida  species (colonizing and infecting isolates) in immunocompromised patients are not the same and acquired resistance was seen in some species.

bmc infectious diseases

Antifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolates