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Background  Hepatic iron overload has been implicated in many liver diseases; however, whether it is involved in clonorchiasis remains unknown. The purpose of this study is to investigate whether  Clonorchis sinensis  ( C. sinensis ) infection causes hepatic iron overload, analyze the relationship between the iron overload and associated cell apoptosis, so as to determine the role of excess iron plays in  C. sinensis -induced liver injury.    Methods  The Perls’ Prussian staining and atomic absorption spectrometry methods were used to investigate the iron overload in hepatic sections of wistar rats and patients infected with  C. sinensis . The hepatic apoptosis was detected by transferase uridyl nick end labeling (TUNEL) methods. Spearman analysis was used for determining the correlation of the histological hepatic iron index and the apoptotic index.    Results  Blue iron particles were deposited mainly in the hepatocytes, Kupffer cells and endothelial cells, around the liver portal and central vein area of both patients and rats. The total iron score was found to be higher in the infected groups than the respective control from 8 weeks. The hepatic iron concentration was also significantly higher in treatment groups than in control rats from 8 weeks. The hepatocyte apoptosis was found to be significantly higher in the portal area of the liver tissue and around the central vein. However, spearman’s rank correlation coefficient revealed that there was a mildly negative correlation between the iron index and hepatocyte apoptosis.    Conclusions  This present study confirmed that hepatic iron overload was found during  C. sinensis  infection. This suggests that iron overload may be associated with hepatocyte apoptosis and involved in liver injury during  C. sinensis  infection. Further studies are needed to investigate the molecular mechanism involved here.

Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection