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Background  The  bla   NDM-1  gene in  Salmonella  species is mostly reported in clinical cases, but is rarely isolated from red and white meat in China.    Methods  A  Salmonella  Indiana ( S. Indiana ) isolate was cultured from a chicken carcass procured from a slaughterhouse in China. Antimicrobial susceptibility was tested against a panel of agents. Whole-genome sequencing of the isolate was carried out and data was analyzed.    Results  A large plasmid, denoted as plasmid pC629 (210,106 bp), containing a composite cassette, consisting of IS 26 - bla   NDM-1 - ble   MBL   -△trpF-tat-cutA- IS CR1-sul1-qacE△1-aadA2-dfrA12-intI1- IS 26  was identified. The latter locus was physically linked with  bla   OXA-1 ,  bla   CTX-M-65 ,  bla   TEM-1 -encoding genes. A mercury resistance operon  merACDEPTR  was also identified; it was flanked on the proximal side, among IS 26  element and the distally located on the  bla   NDM-1  gene. Plasmid pC629 also contained 21 other antimicrobial resistance-encoding genes, such as  aac(6′)-Ib-cr ,  aac(3)-VI ,  aadA5 ,  aph(4)-Ia ,  arr-3 ,  blmS ,  brp ,  catB3 ,  dfrA17 ,  floR ,  fosA ,  mph(A) ,  mphR ,  mrx ,  nimC/nimA ,  oqxA ,  oqxB ,  oqxR ,  rmtB ,  sul1, sul2 . Two virulence genes were also identified on plasmid pC629.    Conclusion  To the best of our knowledge, this is the first report of  bla   NDM-1  gene being identified from a plasmid in a  S. Indiana  isolate cultured from chicken carcass in China.

Genomic characterization of a large plasmid containing a bla NDM-1 gene carried on Salmonella enterica serovar Indiana C629 isolate from China