English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  It has been challenging to determine the true clinical impact of  Acinetobacter  spp., due to the predilection of this pathogen to colonize and infect critically ill patients, who often have a poor prognosis. The aim of this study was to assess whether  Acinetobacter  spp. bacteremia is associated with lower survival compared with bacteremia caused by other pathogens in critically ill patients.    Methods  This study was performed at Hospital das Clínicas, University of São Paulo, Brazil. There are 12 intensive care units (ICUs) in the hospital: five Internal Medicine ICUs (emergency, nephrology, infectious diseases and respiratory critical care), three surgical ICU (for general surgery and liver transplantion), an Emergency Department ICU for trauma patients, an ICU for burned patients, a neurosurgical ICU and a post-operative ICU. A retrospective review of medical records was conducted for all patients admitted to any of the ICUs, who developed bacteremia from January 2010 through December 2011. Patients with  Acinetobacter  spp. were compared with those with other pathogens ( Klebsiella pneumoniae ,  Staphylococcus aureus ,  Enterobacter  spp.,  Enterococcus  spp.,  Pseudomonas aeruginosa ). We did a 30-day survival analysis. The Kaplan-Meier method and log-rank test were used to determine the overall survival. Potential prognostic factors were identified by bivariate and multivariate Cox regression analysis.    Results  One hundred forty-one patients were evaluated. No differences between patients with  Acinetobacter  spp. and other pathogens were observed with regard to age, sex, APACHE II score, Charlson Comorbidity Score and type of infection. Initial inappropriate antimicrobial treatment was more frequent in  Acinetobacter  bacteremia (88 %  vs  51 %). Bivariate analysis showed that age > 60 years, diabetes mellitus, and  Acinetobacter  spp. infection were significantly associated with a poor prognosis. Multivariate model showed that  Acinetobacter  spp. infection (HR = 1.93, 95 % CI: 1.25–2.97) and age > 60 years were independent prognostic factors.    Conclusion   Acinetobacter  is associated with lower survival compared with other pathogens in critically ill patients with bacteremia, and is not merely a marker of disease severity.

Acinetobacter spp. are associated with a higher mortality in intensive care patients with bacteremia: a survival analysis