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Background   Candida parapsilosis  was the most common species causing candidemia in the 2010 China Hospital Invasive Fungal Surveillance Net (CHIF-NET) database. Compared to  Candida albicans , the description of azole resistance and mechanisms in  C. parapsilosis  is very limited. We report a patient with  C. parapsilosis  candidemia over several months, due to a probable intravascular source, who developed fluconazole resistance after prolonged treatment.    Case presentation  An 82 year-old male had a hospital admission of approximately 1.5 years duration. He was initially admitted with acute pancreatitis. Prior to succumbing to the illness, he developed candidemia and treated with three antifungal drugs for nearly 5 months, at suboptimal doses and without source control. Following treatment, 6 blood cultures were still positive for  C. parapsilosis . The last 2 strains were resistant to fluconazole (MICs 32 μg/mL) and intermediate to voriconazole (MICs 0.5 μg/mL). Microsatellite multilocus analysis indicated that the 6 isolates from the patient belonged to a single genotype. The first 4 isolates were susceptible to fluconazole (MICs 2 μg/mL) and voriconazole (MICs 0.015-0.03 μg/mL), which were slightly higher than susceptible control strains from other patients. Overexpression of  MDR1  genes were detected in the two resistant isolates, and this was associated with a homozygous mutation in  MRR1  genes (T2957C /T2957C), with the amino acid exchange L986P.    Conclusions  This case corroborates that the resistant  C. parapsilosis  isolates can emerge in the setting of complicated infections and the extensive use of antifungal agents, emphasizing the need for standardizing and improving the antifungal treatment as well as source control in the treatment of infection diseases.

bmc infectious diseases

Development of fluconazole resistance in a series of Candida parapsilosis isolates from a persistent candidemia patient with prolonged antifungal therapy