English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Mild hyponatremia (serum sodium 130–135 mEq/L) is a common electrolyte disorder in the elderly. However, its association with both sarcopenia and cognitive function remains to be clarified. Therefore, here we investigated the association of mild hyponatremia with skeletal muscle mass, physical function, and cognitive function in the elderly.    Methods  We enrolled 75 participants with mild hyponatremia and 2907 with normonatremia (serum sodium, 136–145 mEq/L) aged ≥70 years who visited the Memory Disorder Outpatient Center of Japan’s National Center for Geriatrics and Gerontology. Skeletal muscle mass index (SMI), grip strength (GS), walking speed (WS), one-leg standing (OLS) test times, and neuropsychological test scores were determined.    Results  One-way analysis of covariance showed that elderly participants with mild hyponatremia had lower SMI (7.1 ± 0.2, 7.2 ± 0.2 kg/m 2 ,  p  = 0.04), weaker GS (19.1 ± 1.9 vs 21.4 ± 1.8 kg,  p  = 0.01), slower WS (0.9 ± 0.1 vs 1.1 ± 0.1 m/s,  p  = 0.001), and higher GDS- 15 score (6.4 ± 0.9 vs 5.2 ± 0.9,  p  = 0.002) than those with normonatremia. Multiple logistic regression analysis indicated that mild hyponatremia was independently associated with sarcopenia (odds ratio [OR]: 2.2,  p  = 0.02), slower WS (OR: 5.3,  p  = 0.04) and shorter OLS time (OR: 2.5,  p  = 0.02) as well as with severe depressive mood (OR: 2.6  p  = 0.006) but not with SMI (OR: 1.6,  p  = 0.2) or GS (OR: 1.9,  p  = 0.09).    Conclusions  Our results suggest that elderly people with even mild hyponatremia had physical function impairment and depressive mood.

Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly