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Background  Injurious falls among older adults are both common and costly. The prevalence of falls is known to increase with age and with use of fall-risk drugs/potentially inappropriate medications (FRD/PIM). Little is known about the joint effects of these two risk factors.    Methods  Data for 2013–2015 were obtained from the Truven Health MarketScan® Medicare database comprising utilization and eligibility (enrollment) data for approximately 4 million enrollees annually. A case-control design was used to compare enrollees aged 65–99 years diagnosed with  >  1 fall event ( n  = 110,625) with enrollees without falls (n = 1,567,412). An exploratory analysis of joint age-FRD/PIM effects on fall risks was based on number needed to harm (NNH) calculations for each FRD/PIM therapy class count (compared with 0 FRD/PIMs), stratified by age group. Logistic regression analyses adjusted for demographics, comorbidities, and fracture history, measured in the 1 year prior to the fall date (cases) or a randomly assigned date (controls).    Results  For each FRD/PIM class count, NNH values decreased with older age (e.g., for 1 FRD/PIM class: from NNH = 333 for ages 65–74 years to NNH = 83 for ages 90–99 years; for 2 FRD/PIM classes: from NNH = 91 for ages 65–74 years to NNH = 38 for ages 90–99 years). NNH decreased to < 15 patients at  >  6 classes for age 65–74 years,  >  5 classes for age 75–84 years, and  >  4 classes for age 85–99 years. Adjusted odds of falling were increased for age-FRD/PIM combinations with smaller NNH values: adjusted odds ratio (AOR) = 1.127 (95% confidence interval [CI] = 1.098–1.156) for NNH = 83–91; AOR = 1.427 (95% CI = 1.398–1.456) for NNH = 17–48; AOR = 1.983 (1.9034–2.032) for NNH < 15.    Conclusion  FRD/PIM use and age appear to have joint effects on fall risk. Older adults at high risk, indicated by small NNH, may be appropriate for fall prevention initiatives, and clinicians may wish to consider decreasing the number of FRD/PIMs utilized by these patients.    Electronic supplementary material  The online version of this article (10.1186/s12877-019-1202-3) contains supplementary material, which is available to authorized users.

Joint effects of advancing age and number of potentially inappropriate medication classes on risk of falls in Medicare enrollees