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Background Protein-losing gastroenteropathy (PLGE) is a syndrome with a chief complaint of hypoalbuminemia, which occurs due to plasma protein leakage in the gastrointestinal tract, leading to general edema, ascites, and pleural effusions. Case presentation A 71-year-old woman visited another hospital for evaluation of hypoalbuminemia and systemic edema. She was hospitalized for a close inspection of hypoalbuminemia and was diagnosed with PLGE. Steroid and azathioprine therapy was prescribed; however, hypoalbuminemia did not improve, and the patient’s condition worsened due to anasarca. As hospitalization was prolonged, the patient was transferred to our hospital. She was infected with  Helicobacter pylori , and we performed  H. pylori  eradication. Following  H. pylori  eradication, her edema improved remarkably. Conclusion We present the first case wherein  H. pylori  eradication successfully improved protein leakage in the lower gastrointestinal tract in a patient diagnosed with PLGE complicated with refractory to immunosuppressant treatment.  H. pylori  eradication should be considered in patients with PLGE complicated with  H. pylori  infection, without specific endoscopic finding or refractory to immunosuppressants.

bmc gastroenterology

Protein-losing gastroenteropathy complicated with asymptomatic primary biliary cholangitis, refractory to immunosuppressant, and improved by Helicobacter pylori eradication: a case report