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Background  Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The  KRAS  status and its prognostic value in CRC remain controversial. This study aimed to investigate the association of  KRAS  status with clinicopathological features and prognostic value in CRC.    Methods  178 colon cancer and 145 rectal cancer patients were enrolled.  KRAS  mutation test was performed on paraffin-embedded tumor samples using PCR methods. The colon cancer was divided into right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Studies that reported the association of  KRAS  mutation with CRC clinical features and prognosis in databases were searched prior to 2018. The data of the present study was combined with the data of published studies using meta-analysis methods.    Results  No significant difference between colon cancer and rectal cancer regarding the  KRAS  status. The  KRAS  mutation was much frequent in RCC than in LCC ( p  = 0.010). 17 studies with 11,385 colon cancer patients were selected, the pooled results of our data and previous published data showed that  KRAS  mutation was more frequent in RCC compared with in LCC ( p  < 0.01);  KRAS  mutation was not associated with the prognosis in RCC patient; however,  KRAS  mutation indicated a poor prognosis in LCC patients compared with  KRAS  wild type ( p  < 0.01).    Conclusion   KRAS  status has no difference between colon cancer and rectal cancer.  KRAS  mutation was more frequent in RCC than in LCC, and associated with a poor prognosis in LCC patients, but not in RCC patients.

Impact of primary colorectal Cancer location on the KRAS status and its prognostic value