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Background  Adult immunization rates are below  Healthy People 2020  targets. Our objective was to evaluate the effectiveness of a multicomponent intervention to improve adult immunization rates.    Methods  This prospective interventional before-and-after non-randomized study was conducted through the American Academy of Family Physicians National Research Network with 43 primary care physicians from a large multi-specialty healthcare organization (multicomponent intervention group  n  = 23; comparator group  n  = 20) in the United States. The multicomponent intervention included provider reminders, quarterly provider-level performance reports, provider education, patient visual aid materials, and standing orders on adult pneumococcal, influenza, and zoster immunizations. We assessed individual and comparative provider-level vaccination rates and missed opportunities detailing concordance with targets established by Healthy People 2020 for pneumococcal, influenza, and zoster immunizations.    Results  Vaccination rates increased after 12 months in intervention and comparator groups respectively for: a). influenza from 44.4 ± 16.7 to 51.3% ± 12.9% (by 6.9 percentage points,  p  = 0.001) and from 35.1 ± 19.1 to 41.3% ± 14.2%, (by 6.2 percentage points,  p  = 0.01); b). pneumococcal vaccinations in older adults from 62.8 ± 17.6 to 81.4% ± 16.6% (by 18.6 percentage points, for  p  < 0.0001) and from 55.9 ± 20.0 to 72.7% ± 18.4% (by 16.7 percentage points,  p  < 0.0001); and c). zoster from 37.1 ± 13.4 to 41.9% ± 13.1% (by 4.8 percentage points,  p  < 0.0001) and from 35.0 ± 18.7 to 42.3% ± 20.9% (7.3 percentage points,  p  = 0.001). Pneumococcal vaccinations in adults at risk did not change from baseline in intervention group (35.7 ± 19.6 to 34.5% ± 19.0%,  p  = 0.3) and improved slightly in comparator group (24.3 ± 20.1 to 28.2% ± 20.0%,  p  = 0.003). Missed opportunities reduced after 12 months, most noticeably, for: a). for influenza from 57.7 to 48.6% (by 9.1 percentage points,  p  < 0.0001) and from 69.7 to 59.6% (by 10.1 percentage points,  p  < 0.0001); b). pneumococcal vaccinations in older adults from 18.1 to 11.5% (by 6.6 percentage points  p  < 0.0001) and from 24.6 to 20.4% (by 4.3 percentage points,  p  < 0.0001) in intervention and comparator groups respectively.    Conclusions  Multicomponent interventions show promise in improving vaccination rates and reducing missed opportunities in older adults for pneumococcal and zoster vaccines and vaccination against influenza. Provider reminders remain the most effective strategy when delivered either as a component of these interventions or alone.

Effects of multicomponent primary care-based intervention on immunization rates and missed opportunities to vaccinate adults