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Background  The purpose of this paper is to systematically review the literature on the relationship between socioeconomic status (SES) and influenza immunization and to examine how certain measures of SES may influence interpretations of this relationship.    Methods  We conducted a systematic review of existing peer-reviewed literature to evaluate the above relationship in the general population. Electronic databases (MEDLINE and EMBASE) were searched from January 2012 to May 2017 to identify English-language studies relevant to this review. Studies were included where influenza vaccination was explicitly reported as the dependent variable and SES as the independent variable. We limited our review to measures of SES that focus on education, income, social class, occupation, and deprivation. Studies that measured SES using other variables (e.g., race, ethnicity, geographic location, rural or urban status, or insurance status) were excluded. Studies were also excluded if they did not report on the human population or did not analyze original data. The population of interest included all age groups, levels of health status, and sociodemographic backgrounds. The review was also limited to World Bank high-income countries. Two authors independently screened full-text articles after obtaining a Kappa score of  K =  0.867. The methodological quality of manuscripts was assessed using the appraisal tools developed by the Joanna Briggs Institute. Results were qualitatively reported and synthesized.    Results  Of the 42 articles included in this review, 52.4% ( n  = 22) found that higher levels of SES resulted in higher levels of influenza vaccination; 4.5% ( n  = 2) reported a negative association; and 14.3% ( n  = 6) found no association. Just over a quarter (26.2%,  n  = 12) of articles reported mixed results.    Conclusions  There was consistently a relationship between SES and influenza immunization, which varied according to how SES was measured. It is recommended that authors be explicit in defining the SES concept they are trying to capture and that they utilize multiple measures of SES (e.g., education, income, class).    Electronic supplementary material  The online version of this article (10.1186/s12874-019-0801-1) contains supplementary material, which is available to authorized users.

The association between influenza vaccination and socioeconomic status in high income countries varies by the measure used: a systematic review