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Background  Ferritin is one of the key proteins that regulate iron homeostasis and is widely available clinical biomarker of iron status. This study aimed to discuss the influence of serum ferritin (SF) on cardiovascular risk factors in the first-degree relatives with family history of type 2 diabetes (FHD).    Methods  This cross-sectional study included 232 men. Anthropometric measurements and blood samples were analyzed. The people were divided into four groups according to median SF (102.8 ng/ml) and people with or without FHD. Group A (FHD–and low SF), group B (FHD–and high SF), group C (FHD+ and low SF), and group D (FHD+ and high SF).    Results  The subjects in different categories of SF concentrations showed significant differences in BMI (SF main effect:  P  = 0.010), WC ( P  = 0.030), SBP ( P  < 0.001), FPG ( P  < 0.001), PPG-2 h ( P  < 0.001), FINS ( P  < 0.001), and HOMA-IR ( P  = 0.015; all: 2-way ANOVA). There was a significant difference in SBP (FHD main effect:  P  = 0.003), DBP ( P  = 0.006), and FINS ( P  = 0.013, all: 2-way ANOVA) between the groups with or without FHD. The interaction term between SF and FHD was significant for SBP ( P  = 0.011), DBP ( P  = 0.012), and PPG-2 h ( P  = 0.022). Logistic analysis showed that accumulation of CVD risk factors, which were ≥ 2 items and ≥ 3 items in group D were 7.546 and 3.343 times higher compared with group A ( P  < 0.05).    Conclusions  The increased SF levels increased the risk of cardiovascular risk factors and the occurrence of insulin resistance in first-degree relatives with FHD.

Serum ferritin, an early marker of cardiovascular risk: a study in Chinese men of first-degree relatives with family history of type 2 diabetes