English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background  The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.    Methods  We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.    Results  A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance ( PHLPP2 , rs78064607,  p  = 3.77 × 10 − 8 ) and 139 (adjusted for all other outcomes) SNPs showed promising association with  p  < 1 × 10 − 5  from the GWAS.    Conclusions  We identified several potential loci, in particular  PHLPP2 ,  BBS9 ,  RyR2 ,  DUSP4  and  HSPA8 , associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.    Trial registration  The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.    Electronic supplementary material  The online version of this article (10.1186/s12872-019-1002-x) contains supplementary material, which is available to authorized users.

bmc cardiovascular disorders

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study